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In a further embodiment, R 7t" is alkoxyalkyl, such as, for example, methoxyethyl. General Function Trna binding Specific Function In the Ecoli 70S ribosome in the initiation state (PubMed:12809609) it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model wi?
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To form the aryl derivative, 7-iodo 4-dedimethylamino sancycline (5B) is treated with an aqueous base (eg, Na 2CO 3) and an appropriate boronic acid (5C) and under an inert atmosphere.
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